Captide Labs

PT-141 Spray | 30mg

$99.99

PT-141 (Bremelanotide) research spray — 30mg per 30ml bottle, 150–500mcg per actuation. Cyclic heptapeptide melanocortin receptor agonist. CAS 189691-06-3. HPLC-MS tested, >98% purity. Third-party tested, ISO 17025 verified. For research use only.

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Description

Melanocortin Receptor Agonist · Research Grade  ·  Performance →

PT-141 (Bremelanotide) Research Spray

Captide Labs PT-141 Spray delivers research-grade Bremelanotide in a pre-formulated, ready-to-use liquid spray format. Each 30ml bottle contains 30mg of PT-141 at greater than 98% purity, independently verified by HPLC-MS analysis and documented with a full Certificate of Analysis. Each actuation delivers 150–500mcg depending on application protocol.

PT-141 (CAS 189691-06-3), also known as Bremelanotide, is a synthetic cyclic heptapeptide analogue of alpha-melanocyte stimulating hormone (α-MSH). It is the only research peptide with an FDA-approved indication specifically related to sexual function — approved in 2019 as Vyleesi® for hypoactive sexual desire disorder (HSDD) in premenopausal women. It operates through a mechanism entirely distinct from vascular-acting compounds, engaging melanocortin receptors in the central nervous system to modulate arousal and desire pathways.

Research Specifications
Compound
PT-141 (Bremelanotide)
CAS Number
189691-06-3
Sequence
Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
Purity
>98% (HPLC-MS Verified)
Molecular Formula
C₅₀H₆₈N₁₄O₁₀
Molecular Weight
1025.18 g/mol
Format
Liquid Spray
Concentration
1mg/ml (30mg / 30ml)
Spray Delivery
150–500mcg per actuation
Bottle Volume
30ml
Total Peptide
30mg
Testing Standard
ISO 17025 Accredited Lab
Storage
Refrigerate at 2–8°C. Do not freeze once in liquid form. Use within 28–30 days of opening.

What is PT-141?

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide derived from Melanotan II research. It is a melanocortin receptor agonist with selective activity at MC3R and MC4R — receptors expressed primarily in the hypothalamus and limbic system, brain regions involved in motivation, reward, and arousal signaling. Unlike PDE5 inhibitors (sildenafil, tadalafil), which act peripherally on vascular smooth muscle, PT-141 acts centrally on the brain’s desire circuitry, representing a mechanistically distinct approach to sexual function research.

PT-141 was originally developed as a tanning agent derived from Melanotan II, but early clinical trials revealed its pronounced pro-sexual effects as a prominent finding. Subsequent development pivoted to sexual dysfunction research, culminating in FDA approval of Bremelanotide (Vyleesi®) in June 2019 for hypoactive sexual desire disorder (HSDD) in premenopausal women — making it the first and only melanocortin-based compound to achieve FDA approval for a sexual health indication.

Research Overview

Areas of active investigation

MC3R & MC4R Receptor Pharmacology
PT-141 is used as an agonist probe for melanocortin receptor subtypes MC3R and MC4R in receptor pharmacology research. MC4R in particular is a well-characterized receptor involved in energy homeostasis, reward signaling, and sexual arousal pathways. Researchers use PT-141 to map ligand-receptor selectivity, downstream cAMP signaling, and second-messenger cascades in controlled in vitro assays and in vivo animal models, providing a well-characterized tool for dissecting melanocortin system function.
Sexual Arousal & Desire Pathway Research
PT-141 has one of the most robust clinical evidence bases of any research peptide in the context of sexual function. Phase 2 and Phase 3 clinical trials (including the RECONNECT trial) demonstrated significant improvements in desire scores and satisfying sexual events versus placebo in women with HSDD. Phase 2 intranasal studies in men with erectile dysfunction also demonstrated statistically significant pro-erectile effects, establishing PT-141’s relevance to both male and female sexual function research models.
Central Nervous System Arousal Mechanisms
Unlike peripherally acting compounds, PT-141’s mechanism operates at the level of the CNS — activating dopaminergic and motivational circuits in the hypothalamus and limbic system. Research has examined how MC4R activation in these regions generates arousal signals independent of vascular or hormonal pathways. This CNS-mediated mechanism makes PT-141 a useful research tool for studying the neurological basis of sexual desire and its intersection with mood, motivation, and reward signaling.
Melanocortin System & Energy Homeostasis
Beyond sexual function, the melanocortin system — and MC4R in particular — plays a well-established role in energy balance, feeding behavior, and metabolic regulation. PT-141’s selective MC3R/MC4R activity, relative to the broader receptor profile of Melanotan II, makes it a useful tool in studies examining melanocortin pathway contributions to energy homeostasis, body weight regulation, and the intersection of metabolic and reproductive signaling.
Intranasal Peptide Delivery Research
Early Phase 2 research on PT-141 used intranasal administration and demonstrated significant pro-erectile effects, establishing the nasal route as a viable delivery pathway for melanocortin peptides. Researchers have continued to investigate intranasal peptide delivery for CNS-active compounds, examining bioavailability, onset kinetics, and the advantages of bypassing hepatic first-pass metabolism via the nasal mucosa’s direct vascular access to systemic circulation.

Related Compound
Explore Semax Research Spray
Researchers investigating CNS-mediated peptide activity frequently investigate PT-141 alongside Semax — an ACTH-derived neuropeptide with a distinct research profile in BDNF modulation, dopaminergic signaling, and broader CNS pathway activation.

Related Compound
Explore NAD+ Research Spray
Researchers studying performance, energy, and CNS optimization frequently pair PT-141 with NAD+ — a coenzyme with a well-established research profile in cellular energy metabolism, mitochondrial function, and neuroprotection.

Third-Party Certificate of Analysis
Every batch of PT-141 Spray is independently tested by an ISO 17025-accredited laboratory. View the full COA including identity confirmation, purity assay, heavy metals, and microbial results.

Frequently Asked Questions

What is PT-141 used for in research?
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PT-141 is used in preclinical and clinical research to study melanocortin receptor pharmacology, CNS-mediated arousal and desire signaling, sexual dysfunction models, and melanocortin system contributions to energy homeostasis. It is the only research peptide with FDA approval for a sexual health indication — approved as Vyleesi® in 2019 for HSDD in premenopausal women — making it one of the most clinically validated compounds in the research peptide catalog.
How does PT-141 differ from PDE5 inhibitors like Viagra?
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PDE5 inhibitors act peripherally — they increase blood flow to genital tissue by inhibiting the phosphodiesterase enzyme that breaks down cGMP in vascular smooth muscle. PT-141 acts centrally, engaging MC3R and MC4R receptors in the hypothalamus and limbic system to modulate the brain’s arousal and desire signaling pathways. This mechanistic distinction makes PT-141 a uniquely valuable research tool for studying the neurological basis of sexual function, independent of vascular mechanisms.
What is the concentration of this spray?
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Each 30ml bottle contains 30mg of PT-141, yielding a concentration of 1mg/ml. Each actuation delivers 150–500mcg depending on the spray protocol used. At 30mg total, this bottle provides substantially more peptide per unit than the 10mg vials typical in the research market — making it well-suited for extended or multi-dose research protocols.
What is the CAS number for PT-141?
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The CAS number for PT-141 (Bremelanotide) is 189691-06-3. Its molecular formula is C₅₀H₆₈N₁₄O₁₀ with a molecular weight of 1025.18 g/mol. It is also referenced under the synonyms Bremelanotide and Vyleesi® (the FDA-approved pharmaceutical form). Its amino acid sequence is Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1).
How does PT-141 relate to Melanotan II?
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PT-141 was derived from Melanotan II research. Melanotan II is a broader melanocortin agonist that activates MC1R (responsible for skin pigmentation), MC3R, MC4R, and MC5R. PT-141 was developed to selectively target the MC3R/MC4R pathway responsible for arousal signaling, while removing the MC1R activity responsible for tanning effects. This selectivity makes PT-141 a more precise research tool for studying sexual function and reward circuitry, without the pigmentation-related variables introduced by full MC1R activation.
How should PT-141 Spray be stored?
+
Store PT-141 Spray refrigerated at 2–8°C. Do not freeze once in liquid form, as freeze-thaw cycling can compromise peptide integrity. Keep away from direct light and heat. Once opened, use within 28–30 days for best results. The cyclic structure of PT-141 contributes to its stability relative to linear peptides, but cold storage is still recommended at all times to preserve maximum potency over the life of the bottle.

For research use only. Not for human consumption, veterinary use, or food/agricultural applications. Not evaluated or approved by the FDA for research use. Not intended to diagnose, treat, cure, or prevent any condition. All purchases are made with the understanding that this compound is strictly for in-vitro research and laboratory use.

FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.

Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.

Handling and Storage Tips:

  • Keep peptides cold and away from light once received.
  • For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
  • Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
  • For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.

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"RUO" is an abbreviation for Research Use Only. It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use.

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Captide Labs PT-141 spray — 30mg Bremelanotide melanocortin receptor agonist research peptide
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