Name: BPC-157 Spray | 30mg | 30ml | Captide Labs
SKU: CPT-SPRY-BPC157-30MG
Price: 109.99 USD
Availability: InStock

Description

Skin & Recovery →·Performance →

BPC-157 Research Spray | Body Protection Compound & Tissue Repair Peptide

Captide Labs BPC-157 Spray delivers research-grade Body Protection Compound in a pre-formulated, ready-to-use liquid spray format. Each 30ml bottle contains 30mg of BPC-157 at greater than 98% purity, independently verified by HPLC-MS analysis and documented with a full Certificate of Analysis. Concentration is 1mg/ml, with each actuation delivering approximately 150–500mcg depending on application protocol.

BPC-157 (CAS 137525-51-0, also referenced as PL-14736), or Body Protection Compound-157, is a synthetic 15-amino acid peptide fragment derived from a protective protein in human gastric juice. First described by Sikiric and colleagues at the University of Zagreb in the early 1990s, it has accumulated one of the largest preclinical evidence bases of any research peptide — spanning tendon and ligament repair, gastrointestinal mucosal protection, angiogenesis, neuroprotection, and systemic anti-inflammatory activity. The liquid spray format provides an alternative to capsule delivery for research protocols where pre-formulated liquid is preferred.

Research Specifications

Compound

BPC-157 (PL-14736)

CAS Number

137525-51-0

Molecular Formula

C₆₂H₉₈N₁₆O₂₂

Molecular Weight

1419.56 g/mol

Peptide Length

15 amino acids (pentadecapeptide)

Purity

>98% (HPLC-MS Verified)

Amino Acid Sequence

Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV)

Format

Liquid Spray

Concentration

1mg/ml

Bottle Volume

30ml

Total Peptide Content

30mg

Spray Delivery

150–500mcg per actuation

Testing Standard

ISO 17025 Accredited Lab

Storage

Refrigerate at 2–8°C. Do not freeze in liquid form. Use within 28–30 days of opening.

What is BPC-157?

BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a partial sequence of a protective protein isolated from human gastric juice. Unlike many research peptides that occur naturally in significant quantities, BPC-157 represents a stable fragment engineered for research utility — it demonstrates remarkable stability in gastric acid and remains active across a wide range of biological environments in preclinical studies, distinguishing it sharply from most peptide compounds.

First described in the scientific literature in the early 1990s by Sikiric and colleagues at the University of Zagreb (Croatia), BPC-157 has since accumulated one of the largest bodies of preclinical evidence of any research peptide. Researchers have characterized multiple signaling pathways involved in its activity, including modulation of the nitric oxide (NO) system, VEGF/angiogenic signaling, FAK-paxillin signaling, JAK2, and ERK1/2 pathways.

Research Overview

Areas of Active BPC-157 Investigation

Tendon, Ligament & Musculoskeletal Repair

BPC-157 has one of the largest preclinical datasets of any research peptide in the context of musculoskeletal repair. Animal models have demonstrated accelerated healing of transected tendons, ligament injuries, and muscle tears, with histological evidence of improved collagen organization and reduced fibrosis. Researchers have investigated its effects on tenocyte proliferation, fibroblast migration, and FAK-paxillin signaling in connective tissue cells.

Gastrointestinal Mucosal Protection

Derived from gastric juice protein, BPC-157 has been extensively studied in GI mucosal healing models — its original characterized application. Preclinical studies have demonstrated protective effects against NSAID-induced gastric ulcers, inflammatory bowel models (cysteamine-colitis), and intestinal anastomosis healing. Researchers have examined its effects on mucosal cell proliferation, tight junction integrity, and COX pathway modulation.

Angiogenesis & Nitric Oxide Signaling

BPC-157 has been shown to upregulate VEGF expression and promote angiogenesis in wound healing models, including tube formation by human umbilical vein endothelial cells (HUVECs) through ERK1/2 phosphorylation. Studies have demonstrated that BPC-157 can modulate NOS activity and that its pro-healing effects may be partly mediated through NO-dependent pathways in vascular and connective tissue.

Neurological & Neuroprotective Research

Preclinical studies have examined BPC-157’s effects in models of traumatic brain injury, spinal cord injury, peripheral nerve damage, and cuprizone-induced demyelination. Researchers have observed improved motor function recovery, reduced neuroinflammation markers, and enhanced nerve regeneration. Its interaction with dopaminergic and serotonergic systems has been investigated in behavioral models.

Cardiovascular Research

A growing body of preclinical work (Sikiric et al., Biomedicines 2022) has investigated BPC-157 in cardiovascular models including myocardial infarction, heart failure, pulmonary hypertension, arrhythmias, and thrombosis — with proposed mechanisms involving NO pathway modulation and angiogenic signaling restoration.

Systemic Anti-Inflammatory Activity

BPC-157 has demonstrated broad anti-inflammatory properties across multiple tissue types in preclinical models. Studies have reported suppression of pro-inflammatory cytokines, modulation of the COX-2 pathway, and reduced NF-κB activation. Its apparent systemic activity following both local and systemic administration has made it a subject of interest in inflammation research across multiple organ systems.

Third-Party Certificate of Analysis

Every batch of BPC-157 Spray is independently tested by an ISO 17025-accredited laboratory. View the full COA including identity confirmation, purity assay, heavy metals, and microbial results on the Captide Labs Lab Reports page.

View COA →

Frequently Asked Questions

What is BPC-157 used for in research?

BPC-157 is used in preclinical research to study tendon and ligament repair, gastrointestinal mucosal healing, angiogenesis, neurological protection, cardiovascular cytoprotection, and systemic anti-inflammatory signaling. It has one of the largest bodies of published preclinical evidence of any research peptide, with studies spanning orthopedics, gastroenterology, neuroscience, cardiology, and dermatology — the majority originating from the Zagreb research group led by Predrag Sikiric since the early 1990s.

What is the concentration of BPC-157 in this spray?

Each 30ml bottle contains 30mg of BPC-157, yielding a concentration of 1mg/ml. Each actuation delivers approximately 150–500mcg depending on the spray pump volume and application protocol. This high-load format provides substantially more total peptide per bottle than most single-peptide spray offerings on the market.

What is BPC-157’s mechanism of action?

BPC-157 appears to act through multiple complementary mechanisms rather than a single defined receptor — which has made characterizing its precise mechanism an active area of research. Documented pathways include modulation of the nitric oxide (NO) system, upregulation of VEGF and angiogenic signaling, FAK-paxillin signaling in tendon and fibroblast cells, JAK2 pathway activity, ERK1/2 phosphorylation in endothelial cells, and modulation of the COX-2 pathway and growth factor receptor expression.

What purity is Captide Labs BPC-157 Spray?

Each batch of BPC-157 Spray meets a minimum purity of greater than 98% as verified by independent HPLC-MS analysis. A full Certificate of Analysis is available on our Lab Reports page for every production batch, including identity confirmation, assay results, heavy metals screening, and microbial limits.

What is the CAS number for BPC-157?

The CAS number for BPC-157 (free base) is 137525-51-0. It is a synthetic 15-amino acid pentadecapeptide with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV), molecular formula C₆₂H₉₈N₁₆O₂₂, and molecular weight 1419.56 g/mol. It is also referenced in the clinical literature as PL-14736 (a Pliva development code).

Why a liquid spray instead of lyophilized powder?

The pre-formulated liquid spray format eliminates the need for reconstitution with bacteriostatic water, a milligram-accurate scale, and sterile handling equipment. It is ready to use from the bottle and provides consistent actuation volume across sprays. BPC-157 demonstrates notable stability in liquid form when refrigerated, making this format practical for research protocols requiring repeated, measured dosing without preparation steps between uses.

How should BPC-157 Spray be stored?

Store BPC-157 Spray refrigerated at 2–8°C. Do not freeze once in liquid form, as freeze-thaw cycling can degrade peptide integrity. Keep away from direct light. Once opened, use within 28–30 days for best results. For longer-term storage of the compound, consider the lyophilized BPC-157 Capsule format, which is stable at -20°C for extended periods.

For research use only. Not for human consumption, veterinary use, or food/agricultural applications. Not evaluated or approved by the FDA. Not intended to diagnose, treat, cure, or prevent any condition. All purchases are made with the understanding that this compound is strictly for in-vitro research and laboratory use. See the full Research Use Only (RUO) Policy.

FDA Disclosure & Intended Use

FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.

Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.

Storage Instructions

Handling and Storage Tips:

Keep peptides cold and away from light once received.
For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.

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Research Use Only (RUO) Policy

"RUO" is an abbreviation for Research Use Only. It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use.

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