Captide Labs

Semax Spray | 50mg

$109.99

Semax research spray — 50mg per 30ml bottle, 200–500mcg per actuation. ACTH-derived neuropeptide. CAS 80714-61-0. Third-party tested, ISO 17025 verified. For research use only.

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Description

ACTH-Derived Neuropeptide · Research Grade  ·  Cognitive →

Semax Research Spray

Captide Labs Semax Spray delivers research-grade Semax in a pre-formulated, ready-to-use liquid spray format. Each 30ml bottle contains 50mg of Semax at greater than 98% purity, independently verified by HPLC-MS analysis and documented with a full Certificate of Analysis. Each actuation delivers 200–500mcg depending on application protocol.

Semax (CAS 80714-61-0) is a synthetic heptapeptide analogue of the ACTH(4–7) fragment, extended with a Pro-Gly-Pro C-terminal motif. Originally developed in Russia in the late 1980s, it has been studied extensively for its neuroprotective and nootropic properties, with a particular focus on BDNF modulation, neurotransmitter system regulation, and ischemia recovery models. It is classified as a prescription drug in Russia and remains one of the most researched peptides in the neurological sciences.

Research Specifications
Compound
Semax (ACTH 4–7 Pro-Gly-Pro)
CAS Number
80714-61-0
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Purity
>98% (HPLC-MS Verified)
Molecular Formula
C₃₇H₅₁N₉O₁₀S
Molecular Weight
813.92 g/mol
Format
Liquid Spray
Concentration
1.67mg/ml (50mg / 30ml)
Spray Delivery
200–500mcg per actuation
Bottle Volume
30ml
Total Peptide
50mg
Testing Standard
ISO 17025 Accredited Lab
Storage
Refrigerate at 2–8°C. Do not freeze once in liquid form. Use within 28–30 days of opening.

What is Semax?

Semax is a synthetic heptapeptide (7 amino acids) derived from a fragment of adrenocorticotropic hormone (ACTH). Specifically, it corresponds to the ACTH(4–7) segment — Met-Glu-His-Phe — extended with a Pro-Gly-Pro C-terminal sequence. This structural modification was engineered to stabilize the peptide against enzymatic degradation and extend its central nervous system activity, while eliminating the hormonal and endocrine activity associated with full-length ACTH.

First developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the late 1980s, Semax has since been approved as a prescription drug in Russia for neurological indications including ischemic stroke recovery and cognitive disorders. Outside of Russia and Eastern Europe, Semax is distributed as a research compound, with an active body of preclinical and clinical literature exploring its mechanisms across neurotrophic, neuroprotective, and cognitive research models.

Research Overview

Areas of active investigation

BDNF & Neurotrophic Factor Modulation
One of the most consistently reported findings in Semax research is its ability to rapidly elevate brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus. BDNF is a key regulator of neuronal survival, synaptic plasticity, and neurogenesis. Rodent studies have reported time-dependent upregulation of BDNF and NGF gene expression in hippocampal and frontal cortical tissue following Semax administration, making it a useful research tool for investigating neurotrophic factor signaling under controlled experimental conditions.
Neuroprotection & Ischemia Research
Semax has been studied extensively in ischemia models, with genome-wide transcriptional analyses reporting broad Semax-associated changes in gene expression across immune- and vascular-system related gene sets in brain tissue following focal ischemia. Preclinical studies have reported increased tolerance to hypoxia, reduced inflammatory markers, and enhanced functional recovery in ischemia-exposed subjects, supporting its use as a research tool in neurovascular and neuroinflammatory pathway investigation.
Dopaminergic & Serotonergic System Research
Semax has been shown to activate dopaminergic and serotonergic brain systems in rodent models, with studies reporting increased serotonin turnover and potentiation of dopamine-related effects following administration. Researchers have used Semax in behavioral models to investigate antidepressant-like and anxiolytic-like activity, stress-response attenuation, and the interplay between neurotrophic signaling and monoaminergic neurotransmission.
Cognitive Function & Neuroplasticity
Preclinical and clinical literature reports Semax-associated improvements in memory, attention, and information processing across a range of experimental paradigms. Imaging studies have documented changes in the rostral subcomponent of the brain’s default mode network (DMN), providing structural correlates for observed cognitive readouts. Semax has also been investigated in developmental models, with studies examining its influence on synaptic plasticity markers and long-term potentiation in controlled settings.
Melanocortin Receptor Interaction
As an ACTH-derived fragment, Semax has been investigated for potential interactions with melanocortin receptors — specifically MC4 and MC5. Experimental evidence suggests Semax may act as a competitive antagonist or partial agonist at these receptors, which are involved in energy regulation, inflammation, and CNS signaling. This receptor interaction profile has made Semax a useful tool in studies examining melanocortin system function distinct from full ACTH’s hormonal effects.

Related Compound
Explore Selank Research Spray
Semax and Selank are frequently co-investigated as complementary neuropeptides — Semax for its activating, nootropic-leaning research profile, and Selank for its anxiolytic and stress-modulating properties. Both are administered intranasally and share enkephalinase-inhibiting mechanisms in preclinical models.

Related Compound
Explore BPC-157 + TB-500 Blend Spray
Researchers running Semax protocols frequently pair it with a systemic repair compound. The BPC-157 + TB-500 Blend Spray combines two of the most studied tissue repair and anti-inflammatory peptides in a single pre-formulated spray — a common complement to cognitive-focused research stacks.

Third-Party Certificate of Analysis
Every batch of Semax Spray is independently tested by an ISO 17025-accredited laboratory. View the full COA including identity confirmation, purity assay, heavy metals, and microbial results.

Frequently Asked Questions

What is Semax used for in research?
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Semax is primarily used in preclinical research to study neurotrophic factor modulation (particularly BDNF and NGF), neuroprotection in ischemia models, dopaminergic and serotonergic system regulation, and cognitive function. It has an established clinical history in Russia as a treatment for stroke recovery, cognitive disorders, and optic nerve disease, and its broad neurological activity makes it a valuable research tool across neuroscience and neuropsychiatry models.
What is the concentration of Semax in this spray?
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Each 30ml bottle contains 50mg of Semax, yielding a concentration of approximately 1.67mg/ml. Each actuation delivers 200–500mcg depending on the spray protocol used. At 50mg total per bottle, this is a higher-load format than the 30mg sprays common in the market — providing more total peptide per bottle for extended or higher-frequency research protocols.
How does Semax relate to ACTH?
+
Semax is a synthetic analogue of the ACTH(4–7) fragment — specifically the Met-Glu-His-Phe portion of the full adrenocorticotropic hormone. It was engineered with a Pro-Gly-Pro C-terminal extension that improves stability and extends duration of CNS activity. Critically, Semax does not reproduce the endocrine and hormonal effects of full-length ACTH — it lacks the adrenocortical-stimulating activity, making it a cleaner research tool for studying the neurotrophic and neuroprotective aspects of ACTH-derived peptide sequences.
What is the CAS number for Semax?
+
The CAS number for Semax is 80714-61-0. It is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro, molecular formula C₃₇H₅₁N₉O₁₀S, and molecular weight 813.92 g/mol. It is also referenced under the synonyms ACTH(4–7) Pro-Gly-Pro and Pro-Gly-Pro-ACTH.
What is the difference between Semax and N-Acetyl Semax?
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N-Acetyl Semax (NA-Semax) is a modified form of Semax with an acetyl group attached to the N-terminus. This modification is thought to further improve enzymatic stability and lipophilicity, potentially influencing CNS penetration and duration of activity. Research on NA-Semax suggests it may produce more potent or prolonged effects in some models. Captide Labs Semax Spray uses the standard (non-acetylated) form, which is the most extensively studied in the published literature and the form used in Russian clinical applications.
How should Semax Spray be stored?
+
Store Semax Spray refrigerated at 2–8°C. Do not freeze once in liquid form, as freeze-thaw cycling can compromise peptide integrity. Keep away from direct light and heat. Once opened, use within 28–30 days for best results. The Russian pharmaceutical formulation of Semax includes a preservative that allows room-temperature stability up to 30°C for short periods — Captide Labs Semax Spray is a research-grade formulation and refrigeration is recommended at all times.

For research use only. Not for human consumption, veterinary use, or food/agricultural applications. Not evaluated or approved by the FDA. Not intended to diagnose, treat, cure, or prevent any condition. All purchases are made with the understanding that this compound is strictly for in-vitro research and laboratory use.

FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.

Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.

Handling and Storage Tips:

  • Keep peptides cold and away from light once received.
  • For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
  • Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
  • For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.

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"RUO" is an abbreviation for Research Use Only. It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use.

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Captide Labs Semax spray — 50mg ACTH-derived BDNF nootropic research peptide
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