Description
ACTH-Derived Neuropeptide · Research Grade · Cognitive →
Semax Research Spray
Captide Labs Semax Spray delivers research-grade Semax in a pre-formulated, ready-to-use liquid spray format. Each 30ml bottle contains 50mg of Semax at greater than 98% purity, independently verified by HPLC-MS analysis and documented with a full Certificate of Analysis. Each actuation delivers 200–500mcg depending on application protocol.
Semax (CAS 80714-61-0) is a synthetic heptapeptide analogue of the ACTH(4–7) fragment, extended with a Pro-Gly-Pro C-terminal motif. Originally developed in Russia in the late 1980s, it has been studied extensively for its neuroprotective and nootropic properties, with a particular focus on BDNF modulation, neurotransmitter system regulation, and ischemia recovery models. It is classified as a prescription drug in Russia and remains one of the most researched peptides in the neurological sciences.
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Compound
Semax (ACTH 4–7 Pro-Gly-Pro)
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CAS Number
80714-61-0
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Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
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Purity
>98% (HPLC-MS Verified)
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Molecular Formula
C₃₇H₅₁N₉O₁₀S
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Molecular Weight
813.92 g/mol
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Format
Liquid Spray
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Concentration
1.67mg/ml (50mg / 30ml)
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Spray Delivery
200–500mcg per actuation
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Bottle Volume
30ml
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Total Peptide
50mg
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Testing Standard
ISO 17025 Accredited Lab
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Storage
Refrigerate at 2–8°C. Do not freeze once in liquid form. Use within 28–30 days of opening.
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What is Semax?
Semax is a synthetic heptapeptide (7 amino acids) derived from a fragment of adrenocorticotropic hormone (ACTH). Specifically, it corresponds to the ACTH(4–7) segment — Met-Glu-His-Phe — extended with a Pro-Gly-Pro C-terminal sequence. This structural modification was engineered to stabilize the peptide against enzymatic degradation and extend its central nervous system activity, while eliminating the hormonal and endocrine activity associated with full-length ACTH.
First developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the late 1980s, Semax has since been approved as a prescription drug in Russia for neurological indications including ischemic stroke recovery and cognitive disorders. Outside of Russia and Eastern Europe, Semax is distributed as a research compound, with an active body of preclinical and clinical literature exploring its mechanisms across neurotrophic, neuroprotective, and cognitive research models.
Areas of active investigation
Frequently Asked Questions
For research use only. Not for human consumption, veterinary use, or food/agricultural applications. Not evaluated or approved by the FDA. Not intended to diagnose, treat, cure, or prevent any condition. All purchases are made with the understanding that this compound is strictly for in-vitro research and laboratory use.





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