Captide Labs

Dihexa Capsules | 10mg | 30 Capsules

$89.99

Research-grade Dihexa capsules. 10mg per capsule, 30 capsules per bottle. HPLC tested, >98% purity. CAS# 1401708-83-5. For research use only.

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1 Bottle
$89.99/ea
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2 BOTTLES
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$80.99/ea
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3 BOTTLES
3 Bottles
$76.49/ea

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Description

HGF/MET Potentiator · Research Grade  ·  Cognitive Collection →

Dihexa Research Capsules

Captide Labs Dihexa capsules provide researchers with a precisely dosed, encapsulated format of one of the most potent cognition-related peptide analogues investigated in preclinical neuroscience research. Each capsule delivers 10mg of Dihexa at greater than 98% purity, independently verified by HPLC-MS analysis and documented with a full Certificate of Analysis.

Dihexa (CAS 1401708-83-5), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is a small peptide analogue derived from angiotensin IV. It acts as a potentiator of hepatocyte growth factor (HGF) signaling at the MET receptor — a pathway with established roles in synaptogenesis, neuronal survival, and cognitive function. Dihexa has been reported in preclinical literature to be orders of magnitude more potent than BDNF in certain hippocampal synaptogenesis assays.

Research Specifications
Compound
Dihexa
CAS Number
1401708-83-5
Also Known As
N-hexanoic-Tyr-Ile-(6)aminohexanoic amide
Purity
>98% (HPLC-MS Verified)
Format
Encapsulated Powder
Amount Per Capsule
10mg
Capsules Per Bottle
30
Testing Standard
ISO 17025 Accredited Lab
Other Ingredients
Gelatin (Vegan), Rice Flour, Silicon Dioxide

What is Dihexa?

Dihexa is a small peptidomimetic compound derived from angiotensin IV (AngIV), developed at Washington State University through structure-activity relationship studies aimed at identifying potent HGF/MET pathway modulators. It was designed to penetrate the blood-brain barrier — a significant challenge for peptide-based neurological research compounds — while retaining potent biological activity at the MET receptor.

The HGF/MET signaling axis plays well-established roles in neuronal development, synaptic plasticity, and neuroprotection. Dihexa’s reported ability to potentiate HGF-mediated MET receptor activation has made it a subject of research interest in models of cognitive decline, neurodegeneration, and hippocampal function — particularly in the context of conditions associated with reduced HGF/MET signaling.

Research Overview

Areas of active investigation

HGF/MET Receptor Potentiation
Dihexa’s primary mechanism involves potentiating hepatocyte growth factor (HGF) binding and signaling at the MET receptor tyrosine kinase. In vitro studies have demonstrated that Dihexa enhances HGF-induced MET phosphorylation and downstream signaling cascades including PI3K/Akt and MAPK/ERK pathways — both implicated in neuronal survival and synaptic plasticity.
Synaptogenesis & Hippocampal Function
Preclinical studies from Washington State University reported that Dihexa significantly increased synaptic connectivity in hippocampal cultures and improved performance in spatial learning tasks in rodent models. These findings positioned Dihexa as a potent tool compound for studying HGF-driven synaptogenesis and hippocampal-dependent memory formation.
Cognitive Decline & Neurodegeneration Models
Animal models of age-related cognitive decline and chemically-induced memory impairment have been used to investigate Dihexa’s effects on learning and memory. Researchers have examined its potential to restore cognitive function in models where HGF/MET signaling is compromised, including scopolamine-induced amnesia and aged rodent models.
Blood-Brain Barrier Penetration
A key research interest is Dihexa’s lipophilicity and reported ability to cross the blood-brain barrier following peripheral administration. Researchers have studied its CNS bioavailability compared to parent AngIV analogues, and its pharmacokinetic profile in rodent models following oral and subcutaneous dosing.
Neuroprotection & Neuronal Survival
HGF/MET signaling is a well-characterized neuroprotective pathway. Researchers have investigated Dihexa in models of oxidative stress-induced neuronal death, examining whether MET potentiation is sufficient to activate pro-survival signaling in neurons under conditions mimicking neurodegenerative pathology.

Third-Party Certificate of Analysis
Every batch of Dihexa capsules is independently tested by an ISO 17025-accredited laboratory. View the full COA including identity confirmation, purity assay, heavy metals, and microbial results.

Frequently Asked Questions

What is Dihexa used for in research?
+
Dihexa is used in neuroscience research as a tool compound for studying HGF/MET receptor signaling, synaptogenesis, hippocampal-dependent cognition, and neuroprotection. It is of particular interest for investigating cognitive decline models and the role of HGF signaling in synaptic plasticity and neuronal survival.
What is Dihexa’s mechanism of action?
+
Dihexa potentiates hepatocyte growth factor (HGF) binding and activity at the MET receptor tyrosine kinase. By enhancing HGF/MET signaling, it activates downstream pathways including PI3K/Akt and MAPK/ERK that regulate neuronal survival, synaptic growth, and plasticity. It is derived from the angiotensin IV framework and was specifically designed for CNS penetration.
What purity is Captide Labs Dihexa?
+
Each batch of Dihexa capsules meets a minimum purity of greater than 98% as verified by independent HPLC-MS analysis. A full Certificate of Analysis is available on our Lab Reports page for every production batch, including identity confirmation, assay results, heavy metals screening, and microbial limits.
What is the CAS number for Dihexa?
+
The CAS number for Dihexa is 1401708-83-5. It is also known as N-hexanoic-Tyr-Ile-(6)aminohexanoic amide and PNB-0408. It was developed at Washington State University as a potent, orally active peptidomimetic HGF/MET potentiator.
How should Dihexa research material be stored?
+
Store Dihexa capsules in a cool, dry place away from direct light. For short-term storage, refrigeration at 4°C is appropriate. For long-term stability, keep at -20°C in an airtight container away from moisture. As a peptidomimetic compound, Dihexa is more stable than full peptides but should still be protected from heat and humidity.

For research use only. Not for human consumption, veterinary use, or food/agricultural applications. Not evaluated or approved by the FDA. Not intended to diagnose, treat, cure, or prevent any condition. All purchases are made with the understanding that this compound is strictly for in-vitro research and laboratory use.

FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.

Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.

Handling and Storage Tips:

  • Keep peptides cold and away from light once received.
  • For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
  • Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
  • For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.

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"RUO" is an abbreviation for Research Use Only. It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use.

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Captide Labs Dihexa capsules — 10mg HGF/MET potentiator nootropic research compound
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