Captide Labs

Orforglipron Capsules | 6mg | 60 Capsules

$179.99

Research-grade Orforglipron capsules. 6mg per capsule, 60 capsules per bottle. HPLC-MS tested, >98% purity. CAS# 2212020-52-3. Oral GLP-1 receptor agonist. For research use only.

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$179.99/ea
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Description

Oral GLP-1 Receptor Agonist · Research Grade  ·  Metabolic Collection →

Orforglipron Research Capsules

Captide Labs Orforglipron capsules provide researchers with a precisely dosed, encapsulated format of one of the most significant small-molecule GLP-1 receptor agonists to emerge from contemporary metabolic drug research. Each capsule delivers 6mg of Orforglipron at greater than 98% purity, independently verified by HPLC-MS analysis and documented with a full Certificate of Analysis.

Orforglipron (CAS 2212020-52-3) is a non-peptidic, oral small-molecule GLP-1 receptor agonist developed by Eli Lilly. Unlike peptide-based GLP-1 agonists which require injection, Orforglipron is orally bioavailable — a property that has made it a subject of intense clinical and preclinical research interest in the fields of obesity, type 2 diabetes, and cardiometabolic disease.

Research Specifications
Compound
Orforglipron
CAS Number
2212020-52-3
Molecular Formula
C₂₄H₂₂F₂N₆O₂
Purity
>98% (HPLC-MS Verified)
Format
Encapsulated Powder
Amount Per Capsule
6mg
Capsules Per Bottle
60
Testing Standard
ISO 17025 Accredited Lab
Other Ingredients
Gelatin (Vegan), Rice Flour, Silicon Dioxide

What is Orforglipron?

Orforglipron is a non-peptidic small molecule that acts as a full agonist at the glucagon-like peptide-1 (GLP-1) receptor. GLP-1 is an incretin hormone secreted by intestinal L-cells in response to food intake, playing central roles in glucose-dependent insulin secretion, glucagon suppression, gastric emptying, and appetite regulation via central nervous system pathways.

What distinguishes Orforglipron from earlier GLP-1 receptor agonists such as semaglutide and liraglutide is its small-molecule, non-peptidic structure — enabling oral bioavailability without the formulation complexity required for oral peptide delivery. It has advanced through Phase 3 clinical trials for type 2 diabetes and obesity, generating significant research interest in its receptor pharmacology, metabolic effects, and potential cardiovascular benefits.

Research Overview

Areas of active investigation

GLP-1 Receptor Pharmacology
As a full GLP-1 receptor agonist, Orforglipron has been studied for its binding affinity, receptor activation kinetics, and downstream signaling profile. Researchers have compared its pharmacological activity against peptidic GLP-1 agonists to characterize similarities and differences in receptor engagement and cAMP signaling cascades.
Glucose Regulation & Insulin Secretion
Clinical trials have demonstrated significant reductions in HbA1c in type 2 diabetes patients, consistent with GLP-1 receptor agonism driving glucose-dependent insulin release and glucagon suppression. Preclinical models have examined the cellular mechanisms underlying these glycemic effects in pancreatic beta cell culture systems.
Body Weight & Appetite Regulation
Phase 2 and Phase 3 clinical data have shown substantial body weight reductions in obese and overweight subjects, driven by GLP-1 receptor-mediated appetite suppression via hypothalamic pathways and delayed gastric emptying. Researchers have investigated the CNS mechanisms underlying the anorectic effects of oral GLP-1 receptor agonism.
Cardiovascular & Cardiometabolic Research
GLP-1 receptor agonists as a class have demonstrated cardiovascular risk reduction in outcome trials. Orforglipron’s cardiovascular effects are under active investigation in Phase 3 trials. Preclinical researchers have examined GLP-1 receptor expression in cardiac tissue and the direct cardioprotective signaling pathways activated by agonism.
Oral Bioavailability & Small-Molecule GLP-1 Agonism
A key area of research interest is Orforglipron’s non-peptidic structure and oral bioavailability. Researchers have studied its absorption, distribution, metabolism, and excretion (ADME) profile, as well as structure-activity relationships that enable small-molecule GLP-1 receptor activation — insights with broad implications for GLP-1 drug discovery.

Related Compound
Explore BAM-15 Research Capsules
Researchers studying metabolic pathways frequently investigate Orforglipron alongside BAM-15 — a selective mitochondrial uncoupler with complementary mechanisms in energy expenditure and insulin sensitivity research.

Third-Party Certificate of Analysis
Every batch of Orforglipron capsules is independently tested by an ISO 17025-accredited laboratory. View the full COA including identity confirmation, purity assay, heavy metals, and microbial results.

Frequently Asked Questions

What is Orforglipron used for in research?
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Orforglipron is used in research to study GLP-1 receptor pharmacology, glucose regulation, appetite signaling, and the metabolic effects of oral small-molecule GLP-1 receptor agonism. It is of particular interest as a tool compound for investigating the mechanisms underlying GLP-1-mediated weight loss and glycemic control without the need for injectable peptide delivery.
How is Orforglipron different from semaglutide?
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Semaglutide is a peptide-based GLP-1 receptor agonist that requires injection (or complex lipid formulation for oral delivery as Rybelsus). Orforglipron is a non-peptidic small molecule with inherent oral bioavailability — no special formulation is required. This structural difference makes Orforglipron a distinct tool compound for receptor pharmacology research and a subject of interest for oral GLP-1 drug development.
What purity is Captide Labs Orforglipron?
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Each batch of Orforglipron capsules meets a minimum purity of greater than 98% as verified by independent HPLC-MS analysis. A full Certificate of Analysis is available on our Lab Reports page for every production batch, including identity confirmation, assay results, heavy metals screening, and microbial limits.
What is the CAS number for Orforglipron?
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The CAS number for Orforglipron is 2212020-52-3. Its molecular formula is C₂₄H₂₂F₂N₆O₂. It is also known by the development code LY3502970 and was developed by Eli Lilly as a non-peptidic oral GLP-1 receptor agonist.
How should Orforglipron research material be stored?
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Store Orforglipron capsules in a cool, dry place away from direct light and humidity. As a small molecule compound, it is stable at room temperature for short-term storage. For long-term preservation, refrigeration at 4°C or freezing at -20°C in an airtight container is recommended. Keep away from moisture and heat.

For research use only. Not for human consumption, veterinary use, or food/agricultural applications. Not evaluated or approved by the FDA. Not intended to diagnose, treat, cure, or prevent any condition. All purchases are made with the understanding that this compound is strictly for in-vitro research and laboratory use.

FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.

Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.

Handling and Storage Tips:

  • Keep peptides cold and away from light once received.
  • For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
  • Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
  • For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.

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"RUO" is an abbreviation for Research Use Only. It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use.

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Captide Labs Orforglipron capsules — 6mg oral GLP-1 receptor agonist research compound
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