Captide Labs

TB-500 Capsules | 500mcg | 60 Capsules

$74.99

Research-grade TB-500 (Thymosin Beta-4) capsules. 500mcg per capsule, 60 capsules per bottle. HPLC tested, >98% purity. CAS# 885340-08-9. For research use only.

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$74.99/ea
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Description

Thymosin Beta-4 · Research Grade  ·  Skin & Recovery Collection →

TB-500 (Thymosin Beta-4) Research Capsules

Captide Labs TB-500 capsules provide researchers with a precisely dosed, encapsulated format of Thymosin Beta-4 — one of the most widely studied tissue repair peptides in preclinical research. Each capsule delivers 500mcg of TB-500 at greater than 98% purity, independently verified by HPLC-MS analysis and documented with a full Certificate of Analysis.

TB-500 is a synthetic analogue of the naturally occurring peptide Thymosin Beta-4 (Tβ4), a 43-amino acid protein ubiquitously expressed in mammalian tissue. With CAS number 885340-08-9, it has been extensively investigated in animal models for its roles in actin sequestration, cell migration, angiogenesis, and inflammation modulation.

Research Specifications
Compound
TB-500 (Thymosin Beta-4)
CAS Number
885340-08-9
Sequence
Ac-SDKPDMAEIEKFDKSKLKKTETQ
Purity
>98% (HPLC-MS Verified)
Format
Encapsulated Powder
Amount Per Capsule
500mcg
Capsules Per Bottle
60
Testing Standard
ISO 17025 Accredited Lab
Other Ingredients
Gelatin (Vegan), Rice Flour, Silicon Dioxide

What is TB-500?

TB-500 is a synthetic peptide derived from the active region of Thymosin Beta-4 (Tβ4), a naturally occurring protein found in virtually all nucleated mammalian cells. Tβ4 is one of the most abundant intracellular peptides in the body and plays a central role in the polymerization of G-actin into F-actin — a process fundamental to cell motility, migration, and tissue organization.

The key active region of TB-500 is a conserved actin-binding domain (LKKTET) that drives much of Tβ4’s biological activity. Researchers have investigated this fragment and its parent molecule across a wide range of preclinical models involving tissue repair, inflammation, cardiac function, and neurological protection.

Research Overview

Areas of active investigation

Actin Sequestration & Cell Migration
TB-500’s primary mechanism involves binding G-actin via its LKKTET domain, regulating the ratio of globular to filamentous actin. This modulation of actin dynamics has been studied in the context of cell migration, wound closure, and tissue remodeling in multiple in-vitro systems.
Tissue Repair & Wound Healing
Animal studies have examined TB-500’s effects on dermal wound healing, corneal repair, and skeletal muscle regeneration. Preclinical models have demonstrated accelerated wound closure and reduced inflammation markers in treated subjects compared to controls.
Angiogenesis & Vascular Research
TB-500 has been investigated for its role in promoting angiogenesis — the formation of new blood vessels from existing vasculature. Research in ischemic tissue models has examined its potential to upregulate VEGF and other pro-angiogenic signaling molecules.
Cardiac & Muscle Research
Studies in rodent models of myocardial infarction have investigated Tβ4 and TB-500 for their effects on cardiomyocyte survival, cardiac progenitor cell activation, and post-infarction remodeling. Skeletal muscle repair following acute injury has also been a focus of preclinical investigation.
Anti-inflammatory Activity
TB-500 has been shown in laboratory models to downregulate pro-inflammatory cytokines including TNF-α and IL-1β. Its capacity to modulate the NF-κB pathway has drawn interest from researchers studying chronic inflammation and autoimmune signaling.

TB-500 in a blend
Also available in GLOW Blend
TB-500 is a key active in our GLOW Blend Capsules — a synergistic stack combining TB-500 with GHK-Cu and BPC-157, formulated for researchers studying multi-compound skin and tissue repair pathways.

Related Compound
Explore GHK-Cu Research Capsules
Researchers studying tissue repair and skin biology frequently investigate TB-500 alongside GHK-Cu (Copper Tripeptide-1) — another well-studied peptide with complementary mechanisms in collagen synthesis and extracellular matrix remodeling.

Third-Party Certificate of Analysis
Every batch of TB-500 capsules is independently tested by an ISO 17025-accredited laboratory. View the full COA including identity confirmation, purity assay, heavy metals, and microbial results.

Frequently Asked Questions

What is TB-500 used for in research?
+
TB-500 (Thymosin Beta-4) is studied in preclinical research for its roles in tissue repair, wound healing, angiogenesis, actin regulation, and anti-inflammatory signaling. It is used in animal models and cell culture systems across disciplines including orthopedics, cardiology, dermatology, and ophthalmology.
What is the difference between TB-500 and Thymosin Beta-4?
+
Thymosin Beta-4 (Tβ4) is the full 43-amino acid naturally occurring peptide. TB-500 is a synthetic analogue based on the key actin-binding region of Tβ4 (the LKKTET domain), which is believed to be responsible for much of Tβ4’s biological activity. TB-500 is more stable and easier to synthesize at research-grade purity than the full Tβ4 sequence.
What purity is Captide Labs TB-500?
+
Each batch of TB-500 capsules meets a minimum purity of greater than 98% as verified by independent HPLC-MS analysis. A full Certificate of Analysis is available on our Lab Reports page for every production batch, including identity confirmation, assay results, heavy metals screening, and microbial limits.
What is the CAS number for TB-500?
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The CAS number for TB-500 is 885340-08-9. It is a synthetic peptide analogue of the actin-binding region of Thymosin Beta-4, a 43-amino acid protein with the sequence Ac-SDKPDMAEIEKFDKSKLKKTETQ.
Why capsules instead of lyophilized TB-500 powder?
+
The capsule format delivers precise, pre-measured 500mcg doses without the need for a milligram-accurate scale or reconstitution equipment. Each capsule acts as a sealed container protecting the peptide from moisture and oxidation during storage and handling. This is a research material — the capsule is a delivery vessel, not a supplement format.
How should TB-500 research material be stored?
+
Store TB-500 capsules in a cool, dry environment away from direct light. For short-term use (weeks), refrigeration at 4°C is appropriate. For long-term storage (months to years), keep at -20°C or below in an airtight container. Avoid repeated freeze-thaw cycles and exposure to humidity.

For research use only. Not for human consumption, veterinary use, or food/agricultural applications. Not evaluated or approved by the FDA. Not intended to diagnose, treat, cure, or prevent any condition. All purchases are made with the understanding that this compound is strictly for in-vitro research and laboratory use.

FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.

Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.

Handling and Storage Tips:

  • Keep peptides cold and away from light once received.
  • For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
  • Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
  • For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.

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"RUO" is an abbreviation for Research Use Only. It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use.

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Captide Labs TB-500 capsules — 500mcg Thymosin Beta-4 tissue repair research peptide
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